DEPBT (3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one) is a peptide coupling reagent notable for its ability to suppress racemization during amide bond formation, making it especially valuable in the synthesis of peptides containing sensitive chiral centers. Unlike traditional reagents such as DCC, HBTU, or HATU, DEPBT does not generate guanidinium or urea byproducts, which simplifies purification and improves product yields. It also avoids the problematic side reactions seen with benzotriazole-based reagents (like HBTU) that can lead to epimerization. Additionally, DEPBT is mild, efficient in both solution-phase and solid-phase synthesis, and is compatible with a wide range of functional groups, making it a versatile choice for chemists seeking high-purity peptide products with minimal racemization.